Src-transformation of mouse fibroblasts induces a Ca2+-activated K+ current without changing the T-type Ca2+ current
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RyR2 Modulates a Ca2+-Activated K+ Current in Mouse Cardiac Myocytes
In cardiomyocytes, Ca2+ entry through voltage-dependent Ca2+ channels (VDCCs) binds to and activates RyR2 channels, resulting in subsequent Ca2+ release from the sarcoplasmic reticulum (SR) and cardiac contraction. Previous research has documented the molecular coupling of small-conductance Ca2+-activated K+ channels (SK channels) to VDCCs in mouse cardiac muscle. Little is known regarding the ...
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The effects of pharmacological agents on the T-type Ca2+ current were studied in dissociated spermatogenic cells from the mouse. Ca2+ currents were elicited by depolarization in 10 mM Ca2+ and recorded in the whole-cell configuration of the patch clamp technique. The T-type current was inhibited by the following compounds: PN200-110 (IC50 = 4 x 10(-8) M) > nifedipine (IC50 = 4 x 10(-7) M) > pim...
متن کاملThe Ca2+-activated K+ current of human sperm is mediated by Slo3
Sperm are equipped with a unique set of ion channels that orchestrate fertilization. In mouse sperm, the principal K(+) current (IKSper) is carried by the Slo3 channel, which sets the membrane potential (Vm) in a strongly pHi-dependent manner. Here, we show that IKSper in human sperm is activated weakly by pHi and more strongly by Ca(2+). Correspondingly, Vm is strongly regulated by Ca(2+) and ...
متن کاملL- and T-type Ca2+ channels in canine cardiac Purkinje cells. Single-channel demonstration of L-type Ca2+ window current.
Canine cardiac Purkinje cells contain both L- and T-type calcium currents, yet the single Ca2+ channels have not been characterized from these cells. Additionally, previous studies have shown an overlap between the steady-state inactivation and activations curves for L-type Ca2+ currents, suggesting the presence of L-type Ca2+ "window" current. We used the on-cell, patch-clamp technique to stud...
متن کاملEstradiol regulates the slow Ca2+-activated K+ current in hippocampal pyramidal neurons.
The slow Ca2+-activated K+ current (sIAHP) was recorded in CA1 pyramidal neurons in hippocampal slices obtained from ovariectomized (OVX) or sham OVX (control) female rats. The sIAHP was significantly larger in cells from OVX rats than in cells from control rats. Superfusion with 5-100 nm 17beta-estradiol (E2) caused a progressive decrease in the sIAHP in cells from OVX rats but not in cells fr...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 1995
ISSN: 0167-4889
DOI: 10.1016/0167-4889(95)00106-3